AboutInVivoMAbanti-humanPD-L1(B7-H1)
The29E.2A3monoclonalantibodyreactswithhumanPD-L1(programmeddeathligand1)alsoknownasB7-H1orCD274.PD-L1isa40kDatypeItransmembraneproteinthatbelongstotheB7familyoftheIgsuperfamily.PD-L1isexpressedonTlymphocytes,Blymphocytes,NKcells,dendriticcells,aswellasIFNγstimulatedmonocytes,epithelialcellsandendothelialcells.PD-L1bindstoitsreceptor,PD-1,foundonCD4andCD8thymocytesaswellasactivatedTandBlymphocytesandmyeloidcells.EngagementofPD-L1withPD-1leadstoinhibitionofTCR-mediatedTcellproliferationandcytokineproduction.PD-L1isthoughttoplayanimportantroleintumorimmuneevasion.InducedPD-L1expressioniscommoninmanytumorsandresultsinincreasedresistanceoftumorcellstoCD8Tcellmediatedlysis.The29E.2A3antibodyhasbeenshowntoblockthebindingofPD-1-IgtoPD-L1.
InVivoMAbanti-humanPD-L1(B7-H1)Specifications
| Isotype | MouseIgG2b, κ |
| RecommendedIsotypeControl(s) | InVivoMAbmouseIgG2bisotypecontrol,unknownspecificity(BE0086) |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer(IP0070) |
| Immunogen | FulllengthhumanPD-L1 |
| ReportedApplications |
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| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Theantibodysolutionshouldbestoredundilutedat4°C,andprotectedfromprolongedexposuretolight.Donotfreeze. |
| RRID | AB_2687808 |
