AboutInVivoMAbanti-mouse/human/ratCD47(IAP)
TheMIAP410monoclonalantibodyreactswithmouseCD47otherwiseknownasintegrin-associatedprotein(IAP).CD47isanapproximately50kDaglycosylatedfivetransmembraneproteinthatisubiquitouslyexpressedbybothhematopoieticcellssuchasTandBlymphocytes,monocytes,plateletsanderythrocytesandnon-hematopoieticcells.CD47isinvolvedinarangeofcellularprocesses,includingapoptosis,proliferation,adhesion,andmigration.FurThermore,itplaysakeyroleinimmuneandangiogenicresponses.CD47isareceptorforthrombospondin-1(TSP-1),asecretedglycoproteinthatplaysaroleinvasculardevelopmentandangiogenesis.CD47Ishasbeenfoundtobeoverexpressedinmanydifferenttumorcells.Becauseofthis,anti-CD47monoclonalantibodieshavebeenproposedandstudiedasatherapeutictreatmentforhumancancers.TheMIAP410antibodyhasbeenshowntoneutralizeCD47invivoandinvitro.
InVivoMAbanti-mouse/human/ratCD47(IAP)Specifications
| Isotype | MouseIgG1, κ |
| RecommendedIsotypeControl(s) | InVivoMAbmouseIgG1isotypecontrol,unknownspecificity(BE0083) |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer(IP0070) |
| Immunogen | purifiedhumanplacentalCD47 |
| ReportedApplications |
|
| Endotoxin |
|
| Purity |
|
| Formulation |
|
| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Theantibodysolutionshouldbestoredundilutedat4°C,andprotectedfromprolongedexposuretolight.Donotfreeze. |
| RRID | AB_2687806 |
