AboutInVivoMAbanti-mouseTIM-1(CD365)
The3B3monoclonalantibodyreactswithmouseTcellimmunoglobulinandmucindomain1(TIM-1)alsoknownasCD365.TIM-1isatypeIcell-surfaceglycoproteinandmemberoftheIgsuperfamily.TIM-1ispreferentiallyexpressedonTH2cellsandhasbeenidentifiedasastimulatorymoleculeforTcellactivation.TheTIMgenefamily,playscriticalrolesinregulatingtheimmuneresponsetoviralinfection.TIM-1isalsoinvolvedinallergicresponses,asthma,andtransplanttolerance.The3B3antibodyisanagoNISTicantibodyandhasbeenshowntoactivateTIM-1invivoandinvitroresultinginthehyperproliferationofTcellsandinductionofproinflammatorycytokineproduction.
InVivoMAbanti-mouseTIM-1(CD365)Specifications
| Isotype | RatIgG2a, κ |
| RecommendedIsotypeControl(s) | InVivoMAbratIgG2aisotypecontrol,anti-trinitrophenol(BE0089) |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer(IP0070) |
| Immunogen | MouseTIM-1(signalandIgVdomains)/mouseIgG2aFcfusionprotein |
| ReportedApplications |
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| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Theantibodysolutionshouldbestoredundilutedat4°C,andprotectedfromprolongedexposuretolight.Donotfreeze. |
| RRID | AB_2687812 |
