AboutInVivoMAbanti-mouseCD40
TheFGK4.5monoclonalantibodyreactswithmouseCD40alsoknownasBp50.CD40isa48kDatypeItransmembraneglycoproteinthatbelongstothetumornecrosisfactorreceptor(TNFR)superfamily.CD40isexpressedbroadlyonantigen-presentingcells(APCs)suchasdendriticcells,Bcells,macrophages,andmonocytesaswellasnon-immuneendothelialcells,basalepithelialcells,andarangeoftumors.UponbindingtoitsligandCD154,CD40actsasacostimulatorymoleculefortheactivationofBcells,dendriticcells,monocytes,andotherAPCs.CD40playsrolesinBcellactivation,differentiation,proliferationandIgisotypeswitchingaswellasdendriticcellmaturation.AgoNISTicCD40monoclonalantibodieshavebeenshowntoactivateAPCsandpromoteanti-tumorTcellresponses.TheFGK4.5antibodyisanagonisticantibodythathasbeenshowntoactivateCD40expressingAPCs.FGK4.5canalsobeusedtoinhibitCD40/CD154interactioninvitroandinvivo.
InVivoMAbanti-mouseCD40Specifications
| Isotype | RatIgG2a |
| RecommendedIsotypeControl(s) | InVivoMAbratIgG2aisotypecontrol,anti-trinitrophenol(BE0089) |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer(IP0070) |
| Immunogen | RecombinantmouseCD40fusionprotein |
| ReportedApplications |
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| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Theantibodysolutionshouldbestoredundilutedat4°C,andprotectedfromprolongedexposuretolight.Donotfreeze. |
| RRID | AB_1107647 |
