AboutInVivoMAbanti-mouseCD103
TheM290monoclonalantibodyreactswithmouseCD103alsoknownasintegrinαE(ITGAE).CD103isanintegrinproteinthatbindsintegrinbeta7toformthecompleteheterodimericintegrinmoleculeαEβ7.CD103isexpressedwidelyonintraepitheliallymphocyte(IEL)Tcells(bothαβTcellsandγδTcells)andonsomeperipheralregulatoryTcells.IthasalsobeenreportedonlaminapropriaTcells.AsubsetofdendriticcellsinthegutmucosaandinmesentericlymphnodesalsoexpressesCD103.ThemainligandforCD103isE-cadherin,anadhesionmoleculeexpressedbyepithelialcells.CD103isthoughttofacilitatetheinteractionsofTcellswithepithelialcellsduringTcellmaturationandeffectorfunctions.TheM290antibodyisreportedtoneutralizeCD103invivo.
InVivoMAbanti-mouseCD103Specifications
| Isotype | RatIgG2a, κ |
| RecommendedIsotypeControl(s) | InVivoMAbratIgG2aisotypecontrol,anti-trinitrophenol(BE0089) |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer(IP0070) |
| Immunogen | Mouseintestinalepithelialcells |
| ReportedApplications |
|
| Endotoxin |
|
| Purity |
|
| Formulation |
|
| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Theantibodysolutionshouldbestoredundilutedat4°C,andprotectedfromprolongedexposuretolight.Donotfreeze. |
| RRID | AB_1107570 |
