AboutInVivoMAbanti-mouseIL-17A
The17F3monoclonalantibodyreactswithmouseIL-17Aa15-20kDacytokineexpressedbyTh17cells,γδTcells,iNKTcells,NKcells,LTicells,neutrophils,andintestinalPanethcells.IL-17Ahaspleiotropiceffectsinimmunoregulationandinflammation.Itplaysanimportantroleinanti-microbialandchronicinflammationbyinducingcytokineandchemokineproduction,neutrophilinflux,andtheproductionofantibacterialpeptidesbutitisalsoaninflammatorymediatorinthedevelopmentofautoimmunediseasesincludingrheumatoidarthritis,asthma,multiplesclerosis,andpsoriasis.The17F3antibodyhasbeenshowntoneutralizeIL-17Ainvivo.
InVivoMAbanti-mouseIL-17ASpecifications
| Isotype | MouseIgG1, κ |
| RecommendedIsotypeControl(s) | InVivoMAbmouseIgG1isotypecontrol,unknownspecificity(BE0083) |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer(IP0070) |
| Immunogen | MouseIL-17Across-linkedtoOVA |
| ReportedApplications | invivoIL-17Aneutralization |
| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Theantibodysolutionshouldbestoredundilutedat4°C,andprotectedfromprolongedexposuretolight.Donotfreeze. |
| RRID | AB_10950102 |
