AboutInVivoPlusanti-mouseCD8α
The53-6.7monoclonalantibodyreactswithmouseCD8α.TheCD8antigenisatransmembraneglycoproteinthatactsasaco-receptorfortheTcellreceptor(TCR).LiketheTCR,CD8bindstoclassIMHCmoleculesdisplayedbyantigenpresentingcells(APC).CD8isprimarilyexpressedonthesurfaceofcytotoxicTcells,butcanalsobefoundonthymocytes,naturalkillercells,andsomedendriticcellsubsets.CD8mostcommonlyexistsasaheterodimercomposedofoneCD8αandoneCD8βchainhowever,itcanalsoexistasahomodimercomposedoftwoCD8αchains.BoththeCD8αandCD8βchainssharesignificanthomologytoimmunoglobulinvariablelightchains.ThemolecularweightofeachCD8chainisapproximately34kDa.The53-6.7antibodyexhibitsdepletingactivitywhenusedinvivo.
InVivoPlusanti-mouseCD8αSpecifications
| Isotype | RatIgG2a, κ |
| RecommendedIsotypeControl(s) | InVivoPlusratIgG2aisotypecontrol,anti-trinitrophenol(BP0089) |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH6.5DilutionBuffer(IP0065) |
| Immunogen | MouseSpleenCellsorThymocyteMembranes |
| ReportedApplications |
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| Endotoxin |
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| BindingValidation | Determinedbyimmunoblot |
| Purity |
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| Aggregation |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Theantibodysolutionshouldbestoredundilutedat4°C,andprotectedfromprolongedexposuretolight.Donotfreeze. |
| MurinePathogenTestResults |
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| RRID | AB_1107671 |
