AboutInVivoPlusanti-mouseCD3ε
The145-2C11monoclonalantibodyreactswithmouseCD3ε,a20kDatransmembranecell-surfaceproteinthatbelongstotheimmunoglobulinsuperfamily.CD3εisoneoffivepolypeptidechainsthatcombinetoformtheTCRcomplex.CD3εisexpressedonTlymphocytes,NK-Tcells,andtovaryingdegreesondevelopingthymocytes.CD3playsrolesinTCRsignaling,Tlymphocyteactivation,andantigenrecognition.The145-2C11antibodyhasbeenshowntoinduceTlymphocyteactivation,proliferation,andapoptosisviabindingandstimulatingtheTCR.Additionally,the145-2C11antibodyhasbeenreportedtoblockthebindingofthe17A2antibodytoCD3ε+Tlymphocytes.
InVivoPlusanti-mouseCD3εSpecifications
| Isotype | ArmenianHamsterIgG1 |
| RecommendedIsotypeControl(s) | InVivoPluspolyclonalArmenianhamsterIgG(BP0091) |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer(IP0070) |
| Immunogen | MouseBM10-37cytotoxicTcells |
| ReportedApplications |
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| Endotoxin |
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| BindingValidation | Determinedbyimmunoblot |
| Purity |
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| Aggregation |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinA |
| Storage | Theantibodysolutionshouldbestoredundilutedat4°C,andprotectedfromprolongedexposuretolight.Donotfreeze. |
| MurinePathogenTestResults |
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| RRID | AB_1107634 |
