AboutInVivoMAbanti-mouseLAG-3
TheC9B7WmonoclonalantibodyreactswithmouseLAG-3alsoknownasCD223.LAG-3isa70kDatypeItransmembraneglycoproteinencodedbytheLag3genethatbelongstotheimmunoglobulinsuperfamily.LAG-3isexpressedbyactivatedTlymphocytes,NKcells,andTregulatorycells.LAG-3’smainligandisMHCclassIIwhichitbindstowithahigheraffinitythanevenCD4does.UponbindingLAG-3isthoughttoplaysimilarrolesasCTLA-4andPD-1includingdownregulationofTCRsignalingandinhibitionofCD4-dependentTcellfunction.LAG-3hasalsobeendemonstratedtocontributetothesuppressorfunctionofTregulatorycells.Incontrasttoinhibition,LAG-3hasbeenshowntopromotesimmuneresponsesbyactivatingantigen-presentingcells.TheC9B7WantibodyhasbeenreportedtoblockthefunctionofmurineLAG-3invivoandinvitrobutstudiessuggestthattheantibodydoesnotblockbindingofLAG-3toMHCclassII.
InVivoMAbanti-mouseLAG-3Specifications
| Isotype | RatIgG1, κ |
| RecommendedIsotypeControl(s) | InVivoMAbratIgG1isotypecontrol,anti-horserADIshperoxidase(BE0088) |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer(IP0070) |
| Immunogen | MouseCD223-Igfusionprotein |
| ReportedApplications |
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| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Theantibodysolutionshouldbestoredundilutedat4°C,andprotectedfromprolongedexposuretolight.Donotfreeze. |
| RRID | AB_10949602 |
