AboutInVivoMAbanti-mouseIL-6R
The15A7monoclonalantibodyreactswiththemouseIL-6receptorαchainalsoknownasCD126.CD126isan80kDatypeIcytokinereceptorandamemberoftheimmunoglobulinsuperfamily.CD126isexpressedbyactivatedTandBlymphocytes,monocytes,hepatocytes,andplasmacells.TheIL-6receptorαchainbindsIL-6butrequiresassociationwithgp130toinitiatesignaltransduction.UponIL-6bindingtheIL-6Rcomplexinfluencesantigen-specificimmuneresponses,inflammatoryresponses,neuronaldevelopment,andisamajormediatoroftheacutephasereaction.The15A7monoclonalantibodyhasbeenshowntoblockthebindingofIL-6totheIL-6receptor.
InVivoMAbanti-mouseIL-6RSpecifications
| Isotype | RatIgG2b, κ |
| RecommendedIsotypeControl(s) | InVivoMAbratIgG2bisotypecontrol,anti-keyholelimpethemocyanin(BE0090) |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer(IP0070) |
| Immunogen | OKT-4hybridomacells |
| ReportedApplications |
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| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinAHighSalt |
| Storage | Theantibodysolutionshouldbestoredundilutedat4°C,andprotectedfromprolongedexposuretolight.Donotfreeze. |
| RRID | AB_1107588 |
