AboutInVivoMAbanti-humanCD44
TheHermes-1monoclonalantibodyreactswithhumanCD44alsoknownasHermes,HCAM,andPgp-1.CD44isan80-95kDaglycoproteinthatisexpressedonallleukocytes,endothelialcells,hepatocytes,andmesenchymalcells.Asanadhesionmolecule,CD44participatesinawidevarietyofcellularfunctionsincludinglymphocyteactivation,recirculationandhoming,andhematopoiesis.CD44isareceptorforhyaluronicacidandcanalsointeractwithotherligands,suchasosteopontin,collagens,andmatrixmetalloproteinases(MMPs).Additionally,CD44isinvolvedintumormetastasisandtargetingofCD44byantibodieshasbeenshowntoreducethemalignantactivitiesofvariousneoplasms.Interestingly,highlevelsoftheadhesionmoleculeCD44onleukemiccellsareessentialtogenerateleukemia.
InVivoMAbanti-humanCD44Specifications
| Isotype | RatIgG2a |
| RecommendedIsotypeControl(s) | InVivoMAbratIgG2aisotypecontrol,anti-trinitrophenol(BE0089) |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer(IP0070) |
| Immunogen | HumanCD44 |
| ReportedApplications |
|
| Endotoxin |
|
| Purity |
|
| Formulation |
|
| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Theantibodysolutionshouldbestoredundilutedat4°C,andprotectedfromprolongedexposuretolight.Donotfreeze. |
| RRID | AB_2687741 |
