AboutInVivoPlusanti-mouseCD8α
The2.43monoclonalantibodyreactswithmouseCD8α.TheCD8antigenisatransmembraneglycoproteinthatactsasaco-receptorfortheTcellreceptor(TCR).LiketheTCR,CD8bindstoclassIMHCmoleculesdisplayedbyantigenpresentingcells(APC).CD8isprimarilyexpressedonthesurfaceofcytotoxicTcells,butcanalsobefoundonthymocytes,naturalkillercells,andsomedendriticcellsubsets.CD8mostcommonlyexistsasaheterodimercomposedofoneCD8αandoneCD8βchainhowever,itcanalsoexistasahomodimercomposedoftwoCD8αchains.BoththeCD8αandCD8βchainssharesignificanthomologytoimmunoglobulinvariablelightchains.ThemolecularweightofeachCD8chainisapproximately34kDa.The2.43antibodyexhibitsdepletingactivitywhenusedinvivo.
InVivoPlusanti-mouseCD8αSpecifications
| Isotype | RatIgG2b, κ |
| RecommendedIsotypeControl(s) | InVivoPlusratIgG2bisotypecontrol,anti-keyholelimpethemocyanin(BP0090) |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer(IP0070) |
| Immunogen | MouseCTLcloneL3 |
| ReportedApplications |
|
| Endotoxin |
|
| BindingValidation | Determinedbyimmunoblot |
| Purity |
|
| Aggregation |
|
| Formulation |
|
| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Theantibodysolutionshouldbestoredundilutedat4°C,andprotectedfromprolongedexposuretolight.Donotfreeze. |
| MurinePathogenTestResults |
|
| RRID | AB_1125541 |
