AboutInVivoPlusanti-mouseCD8α
TheYTS169.4monoclonalantibodyreactswithmouseCD8α.TheCD8antigenisatransmembraneglycoproteinthatactsasaco-receptorfortheTcellreceptor(TCR).LiketheTCR,CD8bindstoclassIMHCmoleculesdisplayedbyantigenpresentingcells(APC).CD8isprimarilyexpressedonthesurfaceofcytotoxicTcells,butcanalsobefoundonthymocytes,naturalkillercells,andsomedendriticcellsubsets.CD8mostcommonlyexistsasaheterodimercomposedofoneCD8αandoneCD8βchainhowever,itcanalsoexistasahomodimercomposedoftwoCD8αchains.BoththeCD8αandCD8βchainssharesignificanthomologytoimmunoglobulinvariablelightchains.ThemolecularweightofeachCD8chainisapproximately34kDa.TheYTS169.4antibodyexhibitsdepletingactivitywhenusedinvivo.
InVivoPlusanti-mouseCD8αSpecifications
| Isotype | RatIgG2b, κ |
| RecommendedIsotypeControl(s) | InVivoPlusratIgG2bisotypecontrol,anti-keyholelimpethemocyanin(BP0090) |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer(IP0070) |
| Immunogen | CBAmousethymocytes |
| ReportedApplications |
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| Endotoxin |
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| BindingValidation | Determinedbyimmunoblot |
| Purity |
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| Aggregation |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Theantibodysolutionshouldbestoredundilutedat4°C,andprotectedfromprolongedexposuretolight.Donotfreeze. |
| MurinePathogenTestResults |
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| RRID | AB_10950145 |
