About InVivoPlus anti-mouse IFNAR-1
The MAR1-5A3 monoclonal antibody reacts with mouse IFNAR-1 (IFN alpha/beta receptor subunit 1). IFNAR-1 is coexpressed with IFNAR-2 on nearly all cell types and together these two subunits make up the heterodimeric Type I IFN Receptor complex. Type I IFNs (IFN-α/β) bind to the Type I IFN Receptor complex to induce cellular responses including induction of anti-viral, anti-microbial, anti-tumor, and autoimmune responses as well as to regulate the activation, proliferation, and differentiation of many cell types. The MAR1-5A3 antibody has been shown to inhibit Type I IFN receptor signaling in vitro and in vivo.
InVivoPlus anti-mouse IFNAR-1 Specifications
| Isotype | Mouse IgG1, κ |
| Recommended Isotype Control(s) | InVivoPlus mouse IgG1 isotype control, unknown specificity(BP0083) |
| Recommended InVivoPure Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer(IP0070) |
| Immunogen | Extracellular domain of mouse IFNAR-1 |
| Reported Applications |
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| Endotoxin |
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| Binding Validation | Determined by immunoblot |
| Purity |
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| Aggregation |
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| Binding Validation | Determined by immunoblot |
| Formulation |
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| Sterility | 0.2 μM filtered |
| Production | Purified from tissue culture supernatant in an animal free facility |
| Purification | Protein G |
| Storage | The antibody solution should be stored undiluted at 4°C, and protected from prolonged exposure to light. Do not freeze. |
| Murine Pathogen Test Results |
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| RRID | AB_2687723 |
