AboutInVivoPlusanti-mouseCSF1R(CD115)
TheAFS98monoclonalantibodyreactswithmousecolonystimulatingfactor1receptor(CSF1R),alsoknownasmacrophagecolony-stimulatingfactorreceptor(M-CSFR),andCD115.CSF1Risasingle-passtypeImembraneproteinandmemberoftheplatelet-derivedgrowthfactorreceptorfamily.InmiceCSF1Risexpressedbymonocytes/macrophages,peritonealexudatecells,plasmacytoidandconventionaldendriticcells,andosteoclasts.CSF1RisareceptorforCSF1andCSF1signalingthroughCSF1Rregulatestheproliferationanddifferentiationofcellsinthemonocyticlineage.TheAFS98antibodyhasbeenreportedtodepletemacrophagesandblockCSFR1invivo.
InVivoPlusanti-mouseCSF1R(CD115)Specifications
| Isotype | RatIgG2a, κ |
| RecommendedIsotypeControl(s) | InVivoPlusratIgG2aisotypecontrol,anti-trinitrophenol(BP0089) |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer(IP0070) |
| Immunogen | Notavailableorunknown |
| ReportedApplications |
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| Endotoxin |
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| BindingValidation | Determinedbyimmunoblot |
| Purity |
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| Aggregation |
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| Formulation |
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| Sterility | 0.2µmfiltration |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Theantibodysolutionshouldbestoredundilutedat4°C,andprotectedfromprolongedexposuretolight.Donotfreeze. |
| MurinePathogenTestResults: |
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| RRID | AB_2687699 |
