AboutInVivoMAbanti-mouseCD8α
The2.43monoclonalantibodyreactswithmouseCD8α.TheCD8antigenisatransmembraneglycoproteinthatactsasaco-receptorfortheTcellreceptor(TCR).LiketheTCR,CD8bindstoclassIMHCmoleculesdisplayedbyantigenpresentingcells(APC).CD8isprimarilyexpressedonthesurfaceofcytotoxicTcells,butcanalsobefoundonthymocytes,naturalkillercells,andsomedendriticcellsubsets.CD8mostcommonlyexistsasaheterodimercomposedofoneCD8αandoneCD8βchainhowever,itcanalsoexistasahomodimercomposedoftwoCD8αchains.BoththeCD8αandCD8βchainssharesignificanthomologytoimmunoglobulinvariablelightchains.ThemolecularweightofeachCD8chainisapproximately34kDa.The2.43antibodyexhibitsdepletingactivitywhenusedinvivo.
InVivoMAbanti-mouseCD8αSpecifications
| Isotype | RatIgG2b, κ |
| RecommendedIsotypeControl(s) | InVivoMAbratIgG2bisotypecontrol,anti-keyholelimpethemocyanin(BE0090) |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer(IP0070) |
| Immunogen | MouseCTLcloneL3 |
| ReportedApplications |
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| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Theantibodysolutionshouldbestoredundilutedat4°C,andprotectedfromprolongedexposuretolight.Donotfreeze. |
| RRID | AB_1125541 |
