AboutInVivoMAbanti-mouseGITR
TheDTA-1monoclonalantibodyreactswithmouseGITR(glucocorticoid-inducedTNFR-relatedgene),a66-70kDaco-stimulatoryimmunecheckpointmoleculebelongingtotheTumorNecrosisFactorsuperfamily(TNFRSF18).GITRisexpressedatlowlevelsonrestingTlymphocytesandathighlevelsonregulatoryTcells.GITRisupregulatedonactivatedTcellswhereitprovidesco-stimulation.GITRligand(GITRL)isfoundonBcells,macrophages,dendriticandendothelialcells,andisimplicatedinregulatingbothinnateandadaptiveimmuneresponses.GITRisalsothoughttoplayakeyroleindominantimmunologicalself-tolerancemaintainedbyregulatoryTcells.KnockoutstudiesinmicealsosuggesttheroleofthisreceptorisintheregulationofCD3-drivenTcellactivationandprogrammedcelldeath.TheDTA-1antibodyisanagoNISTicantibodythatiscommonlyusedtoinduceGITRsignalinginvivo.
InVivoMAbanti-mouseGITRSpecifications
| Isotype | RatIgG2b, λ |
| RecommendedIsotypeControl(s) | InVivoMAbratIgG2bisotypecontrol,anti-keyholelimpethemocyanin(BE0090) |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer(IP0070) |
| Immunogen | MouseCD25+ CD4+ Tcells |
| ReportedApplications | invivoGITRstimulation |
| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Theantibodysolutionshouldbestoredundilutedat4°C,andprotectedfromprolongedexposuretolight.Donotfreeze. |
| RRID | AB_1107688 |
