AboutInVivoMAbanti-mouseCD8(Lyt2.1)
The116-13.1monoclonalantibodyreactswithmouseCD8alsoknownasLyt-2.TheCD8antigenisatransmembraneglycoproteinthatactsasaco-receptorfortheTcellreceptor(TCR).LiketheTCRCD8bindstoclassIMHCmoleculesdisplayedbyantigenpresentingcells(APC).CD8isprimarilyexpressedonthesurfaceofcytotoxicTcellsbutcanalsobefoundonthymocytesnaturalkillercellsandsomedendriticcellsubsets.CD8mostcommonlyexistsasaheterodimercomposedofoneCD8αandoneCD8βchainhoweveritcanalsoexistasahomodimercomposedoftwoCD8αchains.BoththeCD8αandCD8βchainssharesignificanthomologytoimmunoglobulinvariablelightchains.ThemolecularweightofeachCD8chainisapproximately34kDa.The116-13.1antibodyexhibitsdepletingactivitywhenusedinvivo.
InVivoMAbanti-mouseCD8(Lyt2.1)Specifications
| Isotype | MouseIgG2a, κ |
| RecommendedIsotypeControl(s) | InVivoMAbmouseIgG2aisotypecontrol,unknownspecificity(BE0085) |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer(IP0070) |
| Immunogen | CEmousespleencellsandthymocytes |
| ReportedApplications |
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| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Theantibodysolutionshouldbestoredundilutedat4°C,andprotectedfromprolongedexposuretolight.Donotfreeze. |
| RRID | AB_10949065 |
