AboutInVivoPlusanti-mouseCD40L(CD154)
TheMR-1monoclonalantibodyreactswithmouseCD154alsoknownasCD40ligand.CD154existsasa39kDaaccessorymoleculeandbelongstotheTNFsuperfamilyofcytokines.CD154isprimarilyexpressedonthesurfaceofactivatedCD4+Tlymphocytesbutcanalsobeexpressedbyplatelets,mastcells,macrophages,basophils,NKcells,Blymphocytes,CD8+Tlymphocytesaswellasnon-hematopoieticcellsincludingsmoothmusclecells,endothelialcells,andepithelialcells.CD154signalsthroughCD40andisthoughttoplayakeyroleinTandBlymphocytecostimulation.TheMR-1monoclonalantibodyhasbeenreportedtoinhibitinvitroactivationofBlymphocytesbyblockingthebindingofCD154withCD40onThelpercellsaswellasinhibittheformationofgerminalcentersanddisruptantigen-specificTcellresponses.Additionally,theMR-1antibodyblocksinteractionsofTcellsandantigen-presentingcellsinvitroandblocksthedevelopmentofexperimentalautoimmunediseaseinvivo.
InVivoPlusanti-mouseCD40L(CD154)Specifications
| Isotype | ArmenianHamsterIgG |
| RecommendedIsotypeControl(s) | InVivoPluspolyclonalArmenianhamsterIgG(BP0091) |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer(IP0070) |
| Immunogen | ActivatedmouseTh1cloneD1.6 |
| ReportedApplications |
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| Endotoxin |
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| BindingValidation | Determinedbyimmunoblot |
| Purity |
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| Aggregation |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinA |
| Storage | Theantibodysolutionshouldbestoredundilutedat4°C,andprotectedfromprolongedexposuretolight.Donotfreeze. |
| MurinePathogenTestResults |
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| RRID | AB_1107601 |
