AboutInVivoMAbanti-mouseCD25(IL-2Rα)
The7D4monoclonalantibodyreactswithmouseIL-2RαalsoknownasCD25,Ly-43,p55,orTac.IL-2Rαisthe55kDaligand-bindingsubunitoftheinterleukin2receptoralphachain.IL-2RαisexpressedonactivatedmatureTandBlymphocytes,thymocytesubsets,pre-Bcells,andTregulatorycells.IL-2Rαhasbeenshowntoplayrolesinlymphocytedifferentiation,activation,andproliferation.Alone,theIL-2RαbindsIL-2withrelativelylowaffinityhowever,whenIL-2RαassociateswithIL-2Rβ(CD122)andthecommongammachain(CD132)thecomplexbindsIL-2withhighaffinity.The7D4antibodyrecognizesadifferentepitopeonCD25thanthePC-61.5.3clone.
InVivoMAbanti-mouseCD25(IL-2Rα)Specifications
| Isotype | RatIgM, κ |
| RecommendedIsotypeControl(s) | InVivoMAbpolyclonalratIgG(BE0094) |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer(IP0070) |
| Immunogen | IL-2-dependentBALB/cmouseTcellcloneHT2 |
| ReportedApplications | invivoregulatoryTcellinactivation |
| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | T-Gel |
| Storage | Theantibodysolutionshouldbestoredundilutedat4°C,andprotectedfromprolongedexposuretolight.Donotfreeze. |
| RRID | AB_1107615 |
