AboutInVivoPlusanti-mouse/human/rat/monkey/hamster/canine/bovineTGF-β
The1D11.16.8monoclonalantibodyreactswithmouse,human,rat,monkey,hamster,canineandbovineTGF-β(transforminggrowthfactorbeta)isoforms1,2and3.TGF-βisamultifunctionalcytokinethatregulatestheproliferationofepithelialcells,endothelialcells,fibroblasts,neurons,lymphoidcellsincludingTlymphocytesandNKcells,andotherhematopoieticcelltypes.TGF-βalsoregulatestheactivitiesofactivatedmacrophagesandthedevelopmentofregulatoryTcells.Additionally,TGF-βplaysrolesinimmunefunction,tissueremodelingandwoundrepair.TGF-βexistsasfivehighlysimilarisoforms(TGF-β1-5)withhomologiesof70-80%.TGF-β1issynthesizedbytheenzymaticcleavageofalongprecursorTGF-β1polypeptideencodedbytheTGFB1genewhichyieldsthematureproteinandtheLatencyAssociatedPeptide(LAP).TheLAPandmatureTGF-β1non-covalentlyassociateduringsecretion.TGF-βisubiquitouslyexpressedbymanycelltypesincludingmacrophagesandplateletswhichexpresshighlevelsofTGF-β.TGF-βsignalinghasbeenshowntoplaysrolesincancer,autoimmunediseases,asthma,heartdisease,anddiabetes.ItsimportanceisillustratedbyTGF-βknockoutmicewhichshowdefectsinhematopoiesisandendothelialdifferentiation,anddieofoverwhelminginflammation.The1D11.16.8monoclonalantibodyisaneutralizingantibody.
InVivoPlusanti-mouse/human/rat/monkey/hamster/canine/bovineTGF-βSpecifications
| Isotype | MouseIgG1, κ |
| RecommendedIsotypeControl(s) | InVivoPlusmouseIgG1isotypecontrol,unknownspecificity(BP0083) |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer(IP0070) |
| Immunogen | BovineTGFβisoform2 |
| ReportedApplications |
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| Endotoxin |
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| BindingValidation | Determinedbyimmunoblot |
| Purity |
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| Aggregation |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Theantibodysolutionshouldbestoredundilutedat4°C,andprotectedfromprolongedexposuretolight.Donotfreeze. |
| MurinePathogenTestResults |
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| RRID | AB_1107757 |
