AboutInVivoMAbanti-mouseIL-7Rα(CD127)
TheA7R34monoclonalantibodyreactswithmouseIL-7RαalsoknownasCD127.IL-7Rαisa60-90kDatypeItransmembraneglycoproteinexpressedonimmatureBcells,thymocytes,peripheralTcells,andbonemarrowstromalcells.IL-7Rαformsaheterodimerwiththecommonγchain(γcorCD132)anduponligationofIL-7playsimportantrolesinTandBcelldevelopment,andTcellhomeostasis.ThymicStromalLymphopoietin(TSLP)alsobindstoIL-7RαasacomplexwiththeTSLPRchaintotriggeractivationofdendriticcells,andisalsoinvolvedinBcelldevelopment,allergyandautoimmunity.TheA7R34antibodyhasbeenshowntoblockIL-7RαsignalingwhenadmiNISTeredinvivo.
InVivoMAbanti-mouseIL-7Rα(CD127)Specifications
| Isotype | RatIgG2a, κ |
| RecommendedIsotypeControl(s) | InVivoMAbratIgG2aisotypecontrol,anti-trinitrophenol(BE0089) |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer(IP0070) |
| Immunogen | IL-7Rα-IgG1fusionprotein |
| ReportedApplications |
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| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Theantibodysolutionshouldbestoredundilutedat4°C,andprotectedfromprolongedexposuretolight.Donotfreeze. |
| RRID | AB_1107590 |
