TheB6H12monoclonalantibodyreactswithhumanCD47otherwiseknownasintegrin-associatedprotein(IAP),andneurophilin.CD47isanapproximately50kDaglycosylatedfivetransmembraneproteinthatisubiquitouslyexpressedbybothhematopoieticcellssuchasTandBlymphocytes,monocytes,plateletsanderythrocytesandnon-hematopoieticcells.CD47isinvolvedinarangeofcellularprocesses,includingapoptosis,proliferation,adhesion,andmigration.FurThermore,itplaysakeyroleinimmuneandangiogenicresponses.CD47isareceptorforthrombospondin-1(TSP-1),asecretedglycoproteinthatplaysaroleinvasculardevelopmentandangiogenesis.CD47Ishasbeenfoundtobeoverexpressedinmanydifferenttumorcells.Becauseofthis,anti-CD47monoclonalantibodieshavebeenproposedandstudiedasatherapeutictreatmentforhumancancers.TheB6H12antibodyhasbeenshowntoneutralizeCD47andinhibitthegrowthofhepatocellularcarcinomacellsinvitro.
| Isotype | MouseIgG1, κ |
| RecomendedIsotypeControl(s) | InVivoMAbmouseIgG1isotypecontrol,unknownspecificity |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer |
| Immunogen | IntactCD47purifiedfromplacenta |
| ReportedApplications |
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| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Undilutedat4°Cinthedark |
