TheM290monoclonalantibodyreactswithmouseCD103alsoknownasintegrinαE(ITGAE).CD103isanintegrinproteinthatbindsintegrinbeta7toformthecompleteheterodimericintegrinmoleculeαEβ7.CD103isexpressedwidelyonintraepitheliallymphocyte(IEL)Tcells(bothαβTcellsandγδTcells)andonsomeperipheralregulatoryTcells.IthasalsobeenreportedonlaminapropriaTcells.AsubsetofdendriticcellsinthegutmucosaandinmesentericlymphnodesalsoexpressesCD103.ThemainligandforCD103isE-cadherin,anadhesionmoleculeexpressedbyepithelialcells.CD103isthoughttofacilitatetheinteractionsofTcellswithepithelialcellsduringTcellmaturationandeffectorfunctions.TheM290antibodyisreportedtoneutralizeCD103invivo.
| Isotype | RatIgG2a, κ |
| RecomendedIsotypeControl(s) | InVivoMAbratIgG2aisotypecontrol,anti-trinitrophenol |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer |
| Immunogen | Mouseintestinalepithelialcells |
| ReportedApplications |
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| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Undilutedat4°Cinthedark |
