TheM25monoclonalantibodyreactswithmouseandhumanIL-7,a20-28kDahematopoieticgrowthfactorsecretedbystromalcellsinthebonemarrowandthymus.IL-7isalsoproducedbykeratinocytes,dendriticcells,hepatocytes,neurons,andepithelialcells.IL-7bindstotheIL-7receptor,aheterodimerconsistingofIL-7receptoralphaandthecommongammachainreceptor.BindingresultsinstimulationofdifferentiationofpluripotenthematopoieticstemcellsintolymphoidProgenitorcellsandproliferationofalllymphoidcells.IL-7isalsoimportantforproliferationofpre-BcellsaswellasTandNKcellsurvival,developmentandhomeostasis.TheM25antibodyisusefulforneutralizingthebioactivityofIL-7aswellasadmiNISTrationofIL-7cytokine.IL-7administrationasacomplexwithM25prolongsIL-7availABIlityinvivobydecreasingspecificandnonspecificconsumption.
| Isotype | MouseIgG2b |
| RecomendedIsotypeControl(s) | InVivoMAbmouseIgG2bisotypecontrol,unknownspecificity |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer |
| Immunogen | RecombinanthumanIL-7 |
| ReportedApplications |
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| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Undilutedat4°Cinthedark |
