The MJ18 monoclonal antibody reacts with mouse CD276 also known as B7-H3. CD276 is a type I transmembrane protein and a member of the B7 family of co-stimulatory proteins. CD276 is expressed weakly on activated lymphocytes, macrophages, dendritic cells, nasal and airway epithelial cells, osteoblasts, and some tumor cell lines. A soluble form of CD276 is also secreted by monocytes, dendritic cells, and activated T cells. The biological role of CD276 is still under investigation however, recent studies suggest a negative regulatory role for CD276 in T cell responses. The MJ18 antibody has been shown to block CD276 when administered in vivo.
| Isotype | Rat IgG1, κ |
| Recomended Isotype Control(s) |
InVivoMAb rat IgG1 isotype control, anti-horseradish peroxidase InVivoMAb rat IgG1 Isotype control, anti-trinitrophenol |
| Recommended InVivoPure Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Immunogen | Mouse B7-H3 IgG2a fusion protein |
| Reported Applications |
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| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2 μM filtered |
| Production | Purified from tissue culture supernatant in an animal free facility |
| Purification | Protein G |
| Storage | Undiluted at 4°C in the dark |
