The4C9monoclonalantibodyreactswithratbeta2microglobulin(β2M)a12kDacomponentofMHCclassImolecules.β-2-microglobulin,anon-membrane-anchoredglycoprotein,noncovalentlyassociateswiththepolymorphicheavychainofMHCclassImoleculestoformtheHLAclassIantigencomplex.β-2-microglobulinisexpressedonallleukocytes,platelets,endothelialcellsandepithelialcellsandplaysanessentialroleinmediatingproperfoldingandexpressionofMHCclassImolecules.Theimportanceofβ-2-microglobulinisillustratedbyβ-2-microglobulinknockoutmicewhichshowanormaldistributionofTlymphocytes,buthavenomatureCD4orCD8TcellsandarethereforedefectiveinCD4andCD8Tcell-mediatedcytotoxicity.The4C9antibodyrecognizesratβ-2-microglobulinaloneorcomplexedwithFcRnheavychains.
| Isotype | MouseIgG1 |
| RecomendedIsotypeControl(s) | InVivoMAbmouseIgG1isotypecontrol,unknownspecificity |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer |
| Immunogen | SolubleneonatalFcreceptor(FcRn) |
| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Undilutedat4°Cinthedark |
