The UC3-10A6 monoclonal antibody reacts with an epitope on the delta chain of the mouse Vγ2 TCR (V gamma 2 T cell receptor). Vγ2 TCR expressing T lymphocytes make up a large proportion of the γδ T cells in late fetal and adult thymus, peripheral lymphoid tissues, lung, intestinal epithelium, and epidermis. The exact function, ligand, and specificity of γδ TCR-expressing T cells are not completely understood. Studies suggest that these cells recognize bacterial ligands and some tumor cells in the context of MHC class I-like gene products and play a role in regulating the immune response during bacterial infection. The UC3-10A6 antibody has been shown to deplete γδ T cells when administered in vivo.