TheR17217.1.3/TIB-219monoclonalantibodyreactswithmouseCD71alsoknownastransferrinreceptorprotein1(TfR1).CD71isa170-180kDatypeIIhomodimerictransmembraneglycoproteinwhichisexpressedonthesurfaceofproliferatingcells,reticulocytes,anderythroidprecursors.CD71playsaroleinthecontrolofcellularproliferationandisrequiredforironimportfromtransferrinintocellsbyendocytosis.DuetoitsimportantroleinproliferationandcellularironintakeaswellasthefactthatmanycancerouscellsexpresshighlevelsofCD71itisbeingexploredasapotentialnewtargetincasesofhumanleukemia&lymphoma.TheR17217.1.3/TIB-219antibodyhasbeenshowntodepleteCD71+erythroidsplenocytes.
| Isotype | RatIgG2a |
| RecomendedIsotypeControl(s) | InVivoMAbratIgG2aisotypecontrol,anti-trinitrophenol |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer |
| Immunogen | Mouseerythroleukemiacellline745.6 |
| ReportedApplications | invivodepletionofCD71+cells |
| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Undilutedat4°Cinthedark |
