The20H2monoclonalantibodyreactswithmouseCD1dalsoknownasCD1.1.CD1disa48kDatypeImembraneglycoproteinandamemberoftheCD1familyofglycoproteins.CD1disanon-classicalMHCproteinwithstructuralhomologytoclassIMHCmolecules.CD1disexpressedonthesurfaceofvariousantigen-presentingcellsandisinvolvedinthepresentationofnon-peptideglycolipidantigenstotoCD1d-restrictedTcells.CD1d-presentedglycolipidantigensactivateinvariantnaturalkillerT(iNKT)cells,throughtheinteractionwiththeT-cellreceptorpresentoniNKTcellmembranes.Whenactivated,iNKTcellsrapidlyproduceTh1andTh2cytokines.
| Isotype | RatIgG1, κ |
| RecomendedIsotypeControl(s) | InVivoMAbratIgG1Isotypecontrol,anti-trinitrophenol InVivoMAbratIgG1isotypecontrol,anti-horserADIshperoxidase |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer |
| Immunogen | CD1.1-transfectedratcelllineRBL-CD1.1followedbyCD1.1-transfectedhumancelllineCR1-CD1.1 |
| ReportedApplications |
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| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Undilutedat4°Cinthedark |
