TheG28.5monoclonalantibodyreactswithhumanCD40alsoknownasBp50.CD40isa48kDatypeItransmembraneglycoproteinthatbelongstothetumornecrosisfactorreceptor(TNFR)superfamily.CD40isexpressedbroadlyonantigen-presentingcells(APCs)suchasdendriticcells,Bcells,macrophages,andmonocytesaswellasnon-immuneendothelialcells,basalepithelialcells,andarangeoftumors.UponbindingtoitsligandCD154,CD40actsasacostimulatorymoleculefortheactivationofBcells,dendriticcells,monocytes,andotherAPCs.CD40playsrolesinBcellactivation,differentiation,proliferationandIgisotypeswitchingaswellasdendriticcellmaturation.AgoNISTicCD40monoclonalantibodieshavebeenshowntoactivateAPCsandpromoteanti-tumorTcellresponses.TheG28.5antibodyisanagonisticantibodythathasbeenshowntoactivateCD40expressingAPCs.
| Isotype | MouseIgG1, κ |
| RecomendedIsotypeControl(s) | InVivoMAbmouseIgG1isotypecontrol,unknownspecificity |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer |
| Immunogen | Humantonsillarlymphocytes |
| ReportedApplications |
|
| Endotoxin |
|
| Purity |
|
| Formulation |
|
| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Undilutedat4°Cinthedark |
