TheTY/23monoclonalantibodyreactswithmouseCD73alsoknownasecto-5"-nucleotidase(5"-NT),a69kDaGPI-anchoredcell-surfaceprotein.Inmice,expressionofCD73isrestrictedtoCD11b+myeloidcellsinthebonemarrowandTcellsinthespleen.CD73playsastrategicroleincalibratingtheduration,magnitude,andchemicalnatureofpurinergicsignalsdeliveredtoimmunecellsthroughtheconversionofAMPtoadenosine.ThisdrivesashiftfromanATP-drivenproinflammatoryenvironmenttoananti-inflammatorymilieuinducedbyadenosine.CD73hasbeenshowntobeimportantfortheimmunosuppressiveactivityofregulatoryTcells.TheTY/23antibodyhasbeenreportedtoinhibittheenzymaticactivityofCD73.
| Isotype | RatIgG2a, κ |
| RecomendedIsotypeControl(s) | InVivoMAbratIgG2aisotypecontrol,anti-trinitrophenol |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer |
| Immunogen | BALB/cmousespleencellsandCHOcellstransfectedwiththemouseCD73gene |
| ReportedApplications | invivoCD73blockade |
| Endotoxin |
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| Purity |
|
| Formulation |
|
| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Undilutedat4°Cinthedark |
