TheRG9-1monoclonalantibodyreactswithmousegalectin-9a40kDaS-typelectinthatisexpressedbyvariouscelltypesincludinglymphocytes,thymocytes,macrophages,dendriticcells,astrocytes,mastcells,eosinophils,fibroblasts,epithelialcells,andendothelialcells.Galectin-9bindstoβ-galactosidesandcanserveasaligandforTIM-3(CD366).Theproteinisimplicatedinbothinnateandadaptiveimmuneresponsesspecifically,inductionofcytokinesecretionbymacrophages,bactericidalfunctions,promotionofdendriticcellmaturation,regulatoryTcellexpansion,andnegativeregulationofTh1,Th17,NK,andcytotoxicTcells.TheRG9-35antibodyhasbeenreportedtoblocksomeBIOLOGicalactivitiesofGalectin-9whenadmiNISTeredinvivo.
| Isotype | RatIgG2b, κ |
| RecomendedIsotypeControl(s) | InVivoMAbratIgG2bisotypecontrol,anti-keyholelimpethemocyanin |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer |
| Immunogen | Recombinantmousegalectin-9 |
| ReportedApplications | invivoGalectin-9blockade |
| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Undilutedat4°Cinthedark |
