TheIV.3monoclonalantibodyreactswithhumanCD32alsoknownasFcγRIIandFCRII,a40kDapolymorphictransmembraneglycoproteinandanIgsuperfamilymember.CD32isexpressedonmonocytes/macrophages,granulocytes,plateletsandBcells.CD32enablesinteractionbetweenFcγRII-expressingcellsandopsonizedantigenorIgG-containingimmunecomplexes.ThisallowsCD32tofunctionintheactivationorinhibitionofimmuneresponsesincludingdegranulation,phagocytosis,ADCC,cytokinerelease,andBcellproliferation.TheIV.3antibodyhasbeenshowntoblocktheBIOLOGicaleffectsofCD32invitro.Additionally,IV.3f(ab")2fragmentshavebeenusedtoblockCD32invivointransgenicmiceexpressinghumanCD32.
| Isotype | MouseIgG2b |
| RecomendedIsotypeControl(s) | InVivoMAbmouseIgG2bisotypecontrol,unknownspecificity |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer |
| Immunogen | HumanK562leukemiacellline |
| ReportedApplications |
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| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Undilutedat4°Cinthedark |
