TheB122monoclonalantibodyreactswithprecursorandmaturesecretedformsofmouseandratIL-1βa17kDapro-inflammatorycytokineproducedprimarilybymonocytes.IL-1βisanimportantmediatoroftheinflammatoryresponse,andisinvolvedinavarietyofcellularactivities,includingcellproliferation,differentiation,apoptosis,andTandBlymphocyteactivation.IL-1ismadeupofIL-1αandIL-1βwhicharetheproductsofdistinctgenes,butwhicharerecognizedbytwodistinctIL-1receptors.TheIL-1receptortypeI,an80kDatransmembraneproteinwithdemonstratedIL-1signalingfunctionandtheIL-1receptortypeII,a68kDamembraneproteinwitharelativelyshortcytoplasmictail.ThetypeIIreceptoractsasadecoytargetforIL-1,inhibitingIL-1activitiesbypreventingthebindingofIL-1tothetypeIreceptor.TheB122antibodyhasbeenreportedtoneutralizethebioactivityofnaturalorrecombinantIL-1β.
| Isotype | ArmenianHamsterIgG |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer |
| Immunogen | RecombinantmouseIL-1β |
| ReportedApplications |
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| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Undilutedat4°Cinthedark |
