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BioX cell/InVivoMAb anti-mouse CD132 (common γ chain)/BE0271/25MG
The3E12monoclonalantibodyreactswithmouseCD132alsoknownasthecommongammachainandIL-2receptorgammachain.CD132isa64-70kDatypeItransmembraneglycoproteinbelongingtotheIgsuperfamily.ItisexpressedbyawiderangeofcellsincludingTandBlymphocytes,NKcells,monocytes,andgranulocytes.CD132isanessentialsubunitofthereceptorcomplexesforatleastsixdifferentinterleukinreceptors:IL-2,IL-4,IL-7,IL-9,IL-15andIL-21receptors.LigandbindinginducestyrosinephosphorylationandinitiatessignalingthroughtheJAK/STATpathway.The3E12antibodyhasbeenreportedtoblockthebioactivityofIL-4,IL-9,andIL-15andinhibittheligand/receptorbindingofIL-4andIL-7.
| Isotype | RatIgG2b |
| RecomendedIsotypeControl(s) | InVivoMAbratIgG2bisotypecontrol,anti-keyholelimpethemocyanin |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer |
| Immunogen | RatmyelomaYB2/0transfectedwithmousecytoplasmic-taillessCD132 |
| ReportedApplications |
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| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Undilutedat4°Cinthedark |
