The2H7monoclonalantibodyreactswithhumanandprimateCD20.CD20isaBcell-specific33-37kDatransmembraneproteinwhichisalsoknownasB-lymphocyteantigen,B1,andBp35.CD20playsrolesinintracellularcalciumregulationandBcellactivationandiscriticalforanoptimalBcellimmuneresponseagainstT-independentantigens.CD20isfirstexpressedaftertheinductionofCD19togetherwithIgMduringthepre-BtoimmatureBcelltransitioninthebonemarrow.It’sexpressionthenincreasesduringmaturationwithalmostallmatureBcellsexpressingsomelevelofCD20.However,CD20isnotexpressedbyplasmablastsorplasmacells.CD20isexpressedbymostBcellneoplasms,andisusefulindiagnosingBcelllymphomasandleukemia.Manyanti-CD20monoclonalantibodiesarecurrentlybeingusedtosuccessfullytreatleukemia,lymphomas,andvariousautoimmunediseases.The2H7monoclonalantibodyhasbeenshowntobindtoanepitopeinthelargeextracellularloopofhumanCD20.
| Isotype | MouseIgG2b |
| RecomendedIsotypeControl(s) | InVivoMAbmouseIgG2bisotypecontrol,unknownspecificity |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer |
| Immunogen | HumantonsillarBcells |
| ReportedApplications |
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| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Undilutedat4°Cinthedark |
