The GIR-208 monoclonal antibody reacts with the human IFNγR (interferon gamma receptor) α chain also known as CD119 and IFNγ receptor 1. The IFNγR α chain is a 90-100 kDa type I transmembrane protein. CD119 heterodimerizes with the IFNγR β chain to form the IFNγR, a class II cytokine receptor. The IFNγR is expressed ubiquitously on almost all cell types with the exception of mature erythrocytes. Binding of the GIR-208 antibody to IFNγR α is reported to be specifically inhibited in the presence of excess IFNγ. Similarly, the antibody has been reported to block the binding of IFNγ to IFNγR α.
| Isotype | Mouse IgG1 |
| Recomended Isotype Control(s) | InVivoMAb mouse IgG1 isotype control, unknown specificity |
| Recommended InVivoPure Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Immunogen | Purified human IFNγRα chain |
| Reported Applications |
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| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2 μM filtered |
| Production | Purified from tissue culture supernatant in an animal free facility |
| Purification | Protein G |
| Storage | Undiluted at 4°C in the dark |
