The11B11monoclonalantibodyreactswithmouseIL-4(interleukin-4)amultifunctional14kDacytokine.IL-4isexpressedprimarilybyactivatedTh2cellsandNKcells,andatlowerlevelsbymastcells,andbasophils.IL-4signalsthroughtheIL-4Rα.UponreceptorbindingIL-4stimulatesactivatedBandTlymphocyteproliferation,andthedifferentiationofBcellsintoplasmacells.ItalsoinducesBcellclassswitchingtoIgE,andup-regulatesMHCclassIIproductionwhiledecreasingtheproductionofTh1cells,macrophages,IFNγ,anddendriticcellIL-12.LikeotherTh2associatedcytokines,IL-4isinvolvedintheairwayinflammationobservedinthelungsofpatientswithallergicasthma.The11B11monoclonalantibodyhasbeenshowntoneutralizethebioactivityofnaturalorrecombinantIL-4.
| Isotype | RatIgG1, κ |
| RecomendedIsotypeControl(s) | InVivoPlusratIgG1isotypecontrol,anti-horserADIshperoxidase InVivoPlusratIgG1isotypecontrol,anti-trinitrophenol |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer |
| Immunogen | PartiallypurifiednativemouseIL-4 |
| ReportedApplications |
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| Endotoxin |
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| Purity |
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| Aggregation |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Undilutedat4°Cinthedark |
| MurinePathogenTestResults |
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