The1B1.3AmonoclonalantibodyreactswithmouseIL-10R(IL-10receptor)alsoknownasCD210.TheIL-10RisaclassIIcytokinereceptorandisexpressedbyavarietyofcelltypesincludingthymocytes,Tlymphocytes,Blymphocytes,NKcells,monocytes,andmacrophages.UponbindingIL-10,IL-10Rstimulationresultsinmanypleiotropic,effectsinimmunoregulationandinflammation.IL-10Rdownregulatestheexpressionofpro-inflammatorycytokines,MHCclassIIantigens,andco-stimulatorymoleculesonmacrophages.ItalsoenhancesBlymphocytesurvival,proliferation,andantibodyproduction.IL-10RsignalingcanblockNF-κBactivity,andisinvolvedintheregulationoftheJAK-STATsignalingpathway.The1B1.3AantibodyisaneutralizingantibodyandhasbeenshowntoblockthebindingofhumanIL-10,whichcross-reactswiththemouseIL-10R.However,thisclonedoesnotrecognizethehumanIL-10R.
| Isotype | RatIgG1, κ |
| RecomendedIsotypeControl(s) | InVivoPlusratIgG1isotypecontrol,anti-horserADIshperoxidase InVivoPlusratIgG1isotypecontrol,anti-trinitrophenol |
| Immunogen | Recombinantligand-bindingdomainofmouseIL-10R |
| ReportedApplications |
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| Endotoxin |
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| Purity |
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| Aggregation |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Undilutedat4°Cinthedark |
| MurinePathogenTestResults |
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