TheXMG1.2monoclonalantibodyreactswithmouseIFNγ(interferongamma)a20kDasolublepleiotropiccytokineandthesolememberofthetypeIIclassofinterferons.IFNγisprimarilyproducedbyactivatedlymphocytesincludingT,B,NKcells,andILCs.IFNγexertsimmunoregulatory,anti-proliferative,anti-viral,andproinflammatoryactivitiesandplaysanimportantroleinactivation,growth,anddifferentiationofTandBlymphocytes,macrophages,NKcellsandothernon-hematopoieticcelltypes.Additionally,IFNγinducestheproductionofcytokines,Fcreceptor,andadhesionmoleculesandup-regulatesMHCclassIandIIantigenexpressionbyantigenpresentingcellsduringanimmuneresponse.IFNγhasalsobeenshowntomodulatemacrophageeffectorfunctions,influenceisotypeswitchingandinducethesecretionofimmunoglobulinsbyBcells.IFNγsignalsthroughtheIFNgammareceptorwhichexistsasaheterodimercomposedofCD119(IFNgammareceptor1)andAF-1(IFNgammareceptor2).TheIFNγreceptorisexpressedubiquitouslyonalmostallcelltypeswiththeexceptionofmatureerythrocytes.TheXMG1.2antibodyisaneutralizingantibody.
| Isotype | RatIgG1, κ |
| RecomendedIsotypeControl(s) | InVivoPlusratIgG1isotypecontrol,anti-horserADIshperoxidase InVivoPlusratIgG1isotypecontrol,anti-trinitrophenol |
| Immunogen | RecombinantmouseIFNγ |
| ReportedApplications |
|
| Endotoxin |
|
| Purity |
|
| Aggregation |
|
| Formulation |
|
| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Undilutedat4°Cinthedark |
| MurinePathogenTestResults |
|
