The10F.9G2monoclonalantibodyreactswithmousePD-L1(programmeddeathligand1)alsoknownasB7-H1orCD274.PD-L1isa40kDatypeItransmembraneproteinthatbelongstotheB7familyoftheIgsuperfamily.PD-L1isexpressedonTlymphocytes,Blymphocytes,NKcells,dendriticcells,aswellasIFNγstimulatedmonocytes,epithelialcellsandendothelialcells.PD-L1bindstoitsreceptor,PD-1,foundonCD4andCD8thymocytesaswellasactivatedTandBlymphocytesandmyeloidcells.EngagementofPD-L1withPD-1leadstoinhibitionofTCR-mediatedTcellproliferationandcytokineproduction.PD-L1isthoughttoplayanimportantroleintumorimmuneevasion.InducedPD-L1expressioniscommoninmanytumorsandresultsinincreasedresistanceoftumorcellstoCD8Tcellmediatedlysis.Inmousemodelsofmelanoma,tumorgrowthcanbetransientlyarrestedviatreatmentwithantibodieswhichblocktheinteractionbetweenPD-L1andPD-1.The10F.9G2antibodyhasbeenshowntoblocktheinteractionbetweenPD-L1andPD-1andbetweenPD-L1andB7-1(CD80).
Isotype | RatIgG2b, κ |
RecomendedIsotypeControl(s) | InVivoPlusratIgG2bisotypecontrol,anti-keyholelimpethemocyanin |
RecommendedInVivoPureDilutionBuffer | InVivoPurepH6.5DilutionBuffer |
Immunogen | MouseCD274 |
ReportedApplications |
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Endotoxin |
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Purity |
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Aggregation |
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Formulation |
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Sterility | 0.2μMfiltered |
Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
Purification | ProteinG |
Storage | Undilutedat4°Cinthedark |
MurinePathogenTestResults |
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