The9H10monoclonalantibodyreactswithmouseCTLA-4(cytotoxicTlymphocyteantigen-4)alsoknownasCD152.CTLA-4isa33kDacellsurfacereceptorencodedbytheCtla4genethatbelongstotheCD28familyoftheIgsuperfamily.CTLA-4isexpressedonactivatedTandBlymphocytes.CTLA-4isstructurallysimilartotheT-cellco-stimulatoryprotein,CD28,andbothmoleculesbindtotheB7familymembersB7-1(CD80)andB7-2(CD86).Uponligandbinding,CTLA-4negativelyregulatescell-mediatedimmuneresponses.CTLA-4playsrolesininductionand/ormaintenanceofimmunologicaltolerance,thymocytedevelopment,andregulationofprotectiveimmunity.ThecriticalroleofCTLA-4inimmunedown-regulationhasbeendemonstratedinCTLA-4deficientmice,whichsuccumbat3-5weeksofageduetothedevelopmentofalymphoproliferativedisease.CTLA-4isamongagroupofinhibitoryreceptorsbeingexploredascancertreatmenttargetsthroughimmunecheckpointblockade.The9H10antibodyhasbeenshowntopromoteTcellco-stimulationbyblockingCTLA-4bindingtotheB7co-receptors,allowingforCD28binding.
| Isotype | SyrianHamsterIgG |
| RecomendedIsotypeControl(s) | InVivoPluspolyclonalSyrianhamsterIgG |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer |
| Immunogen | MouseCTLA-4-humanIgG1fusionprotein |
| ReportedApplications |
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| Endotoxin |
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| Purity |
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| Aggregation |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Undilutedat4°Cinthedark |
| MurinePathogenTestResults |
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