The9D9monoclonalantibodyreactswithmouseCTLA-4(cytotoxicTlymphocyteantigen-4)alsoknownasCD152.CTLA-4isa33kDacellsurfacereceptorencodedbytheCtla4genethatbelongstotheCD28familyoftheIgsuperfamily.CTLA-4isexpressedonactivatedTandBlymphocytes.CTLA-4isstructurallysimilartotheT-cellco-stimulatoryprotein,CD28,andbothmoleculesbindtotheB7familymembersB7-1(CD80)andB7-2(CD86).Uponligandbinding,CTLA-4negativelyregulatescell-mediatedimmuneresponses.CTLA-4playsrolesininductionand/ormaintenanceofimmunologicaltolerance,thymocytedevelopment,andregulationofprotectiveimmunity.ThecriticalroleofCTLA-4inimmunedown-regulationhasbeendemonstratedinCTLA-4deficientmice,whichsuccumbat3-5weeksofageduetothedevelopmentofalymphoproliferativedisease.CTLA-4isamongagroupofinhibitoryreceptorsbeingexploredascancertreatmenttargetsthroughimmunecheckpointblockade.
Isotype | MouseIgG2b |
RecomendedIsotypeControl(s) | InVivoPlusmouseIgG2bisotypecontrol,unknownspecificity |
RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer |
Immunogen | Notavailableorunknown |
ReportedApplications |
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Endotoxin |
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Purity |
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Aggregation |
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Formulation |
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Sterility | 0.2μMfiltered |
Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
Purification | ProteinA |
Storage | Undilutedat4°Cinthedark |
MurinePathogenTestResults |
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