TheLOB12.3monoclonalantibodyreactswithmouse4-1BB,aTNFreceptorsuperfamilymemberalsoknownasCD137.4-1BBisa39kDatransmembraneproteinexpressedbyTlymphocytes,NKcells,dendriticcells,granulocytes,andmastcells.Uponbindingitsligand4-1BBL,4-1BBprovidescostimulatorysignalstobothCD4andCD8TcellsthroughtheactivationofNF-κB,c-Junandp38downstreampathways.Theimportanceofthe4-1BBpathwayhasbeenunderscoredinanumberofdiseases,includingcancer.AgoNISTicanti-4-1BBantibodieshavebeenreportedtoinduceTcellmediatedantitumorimmunity.TheLOB12.3antibodyisanagonisticantibodythathasbeenshowntostimulate4-1BBsignalinganddelaytumorgrowthinvivowhenadministeredincombinationwithimmunecheckpointinhibitors.
| Isotype | RatIgG1 |
| RecomendedIsotypeControl(s) | InVivoPlusratIgG1isotypecontrol,anti-trinitrophenol InVivoPlusratIgG2aisotypecontrol,anti-trinitrophenol |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH8.0DilutionBuffer |
| Immunogen | MouseCD137humanFcfusionprotein |
| ReportedApplications | invivoactivationof4-1BB |
| Endotoxin |
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| Purity |
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| Aggregation |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Undilutedat4°Cinthedark |
| MurinePathogenTestResults |
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