TheC9B7WmonoclonalantibodyreactswithmouseLAG-3alsoknownasCD223.LAG-3isa70kDatypeItransmembraneglycoproteinencodedbytheLag3genethatbelongstotheimmunoglobulinsuperfamily.LAG-3isexpressedbyactivatedTlymphocytes,NKcells,andTregulatorycells.LAG-3’smainligandisMHCclassIIwhichitbindstowithahigheraffinitythanevenCD4does.UponbindingLAG-3isthoughttoplaysimilarrolesasCTLA-4andPD-1includingdownregulationofTCRsignalingandinhibitionofCD4-dependentTcellfunction.LAG-3hasalsobeendemonstratedtocontributetothesuppressorfunctionofTregulatorycells.Incontrasttoinhibition,LAG-3hasbeenshowntopromotesimmuneresponsesbyactivatingantigen-presentingcells.TheC9B7WantibodyhasbeenreportedtoblockthefunctionofmurineLAG-3invivoandinvitrobutstudiessuggestthattheantibodydoesnotblockbindingofLAG-3toMHCclassII.
| Isotype | RatIgG1, κ |
| RecomendedIsotypeControl(s) | InVivoPlusratIgG1isotypecontrol,anti-horserADIshperoxidase InVivoPlusratIgG1isotypecontrol,anti-trinitrophenol |
| RecommendedInVivoPureDilutionBuffer | InVivoPurepH7.0DilutionBuffer |
| Immunogen | MouseCD223-Igfusionprotein |
| ReportedApplications |
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| Endotoxin |
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| Purity |
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| Aggregation |
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| Formulation |
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| Sterility | 0.2μMfiltered |
| Production | Purifiedfromtissueculturesupernatantinananimalfreefacility |
| Purification | ProteinG |
| Storage | Undilutedat4°Cinthedark |
| MurinePathogenTestResults |
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