The MAR1-5A3 monoclonal antibody reacts with mouse IFNAR-1 (IFN alpha/beta receptor subunit 1). IFNAR-1 is coexpressed with IFNAR-2 on nearly all cell types and together these two subunits make up the heterodimeric Type I IFN Receptor complex. Type I IFNs (IFN-α/β) bind to the Type I IFN Receptor complex to induce cellular responses including induction of anti-viral, anti-microbial, anti-tumor, and autoimmune responses as well as to regulate the activation, proliferation, and differentiation of many cell types. The MAR1-5A3 antibody has been shown to inhibit Type I IFN receptor signaling in vitro and in vivo.
Isotype | Mouse IgG1 |
Recomended Isotype Control(s) | InVivoPlus mouse IgG1 isotype control, unknown specificity |
Recommended InVivoPure Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
Immunogen | Extracellular domain of mouse IFNAR-1 |
Reported Applications |
|
Endotoxin |
|
Purity |
|
Aggregation |
|
Formulation |
|
Sterility | 0.2 μM filtered |
Production | Purified from tissue culture supernatant in an animal free facility |
Purification | Protein G |
Storage | Undiluted at 4°C in the dark |
Murine Pathogen Test Results |
|