About InVivoMAb anti-mouse CLEC9A (CD370)
The 7H11 monoclonal antibody reacts with mouse CLEC9A (C-type lectin domain family member 9A). CLEC9A, also known as DNGR1 (dendritic cell natural killer lectin group receptor 1) and CD370, is a type II transmembrane glycoprotein with a single extracellular C-type lectin domain. DNGR-1 is restricted in its expression, being found only on CD8α+, CD103+, CD11b− subsets of DCs and plasmacytoid DCs. CLEC9A reportedly functions as an endocytic receptor for necrotic cells. It can mediate the cross-presentation of dead-cell associated antigens by dendritic cells in a Syk-dependent manner. It has been shown that targeting antigen to DNGR-1 on DC’s via coupling antigen to the 7H11 antibody can result in activation of antigen specific CD8+ T cell responses in vivo.
InVivoMAb anti-mouse CLEC9A (CD370) Specifications
| Isotype | Rat IgG1, κ |
| Recommended Isotype Control(s) | InVivoMAb rat IgG1 isotype control, anti-horseradish peroxidase(BE0088) |
| Recommended InVivoPure Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer(IP0070) |
| Immunogen | RBL-2H3 cells expressing mouse CLEC9A fused to an HA epitope |
| Reported Applications | in vivo Ag targeting to CLEC9A+ DCs Western blot ELISA Immunoprecipitation Immunofluorescence Flow cytometry |
| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2 μM filtered |
| Production | Purified from tissue culture supernatant in an animal free facility |
| Purification | Protein G |
| RRID | AB_2721034 |
| Molecular Weight | 150 kDa |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
