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当前位置: 首页 > 产品中心 > Isotype_control_antibody > BioXcell/InVivoMAb polyclonal Syrian hamster IgG/DISCOUNTED ACADEMIC OR NON PROFIT: 25MG/BE0087-A025mg
商品详细BioXcell/InVivoMAb polyclonal Syrian hamster IgG/DISCOUNTED ACADEMIC OR NON PROFIT: 25MG/BE0087-A025mg
BioXcell/InVivoMAb polyclonal Syrian hamster IgG/DISCOUNTED ACADEMIC OR NON PROFIT: 25MG/BE0087-A025mg
BioXcell/InVivoMAb polyclonal Syrian hamster IgG/DISCOUNTED ACADEMIC OR NON PROFIT: 25MG/BE0087-A025mg
商品编号: BE0087-A025mg
品牌: BioXcell inc
市场价: ¥1900.00
美元价: 1140.00
产地: 美国(厂家直采)
公司:
产品分类: 同型对照抗体
公司分类: Isotype_control_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

About InVivoMAb anti-mouse IL-27 p28

The MM27.7B1 monoclonal antibody reacts with the p28 subunit of mouse IL-27, a member of the IL-6/IL-12 cytokine family. IL-27 is a heterodimeric cytokine composed the EBI3 (Epstein-Barr virus induced gene 3) protein and the p28 subunit, also known as IL-30. Myeloid cells including macrophages, inflammatory monocytes, microglia, and dendritic cells are the dominant cellular sources of IL-27. These cells secrete IL-27 in response to TLR ligands and inflammatory cytokines. IL-27 p28 signals through IL-27 receptors (IL-27R) which are highly expressed by NK cells and activated T cells and to a lesser extent on B cells, naïve T cells, and others. IL-27 signaling has been shown to have both pro-inflammatory and anti-inflammatory effects. Signaling through IL-27R promotes Th1 polarization and IFNγ production but also suppresses the differentiation and proliferation of Th2 and Th17 cells and induces the expression of IL-10. The MM27.7B1 clone has been shown to neutralize the bioactivity of mouse IL-27 in vivo and in vitro and reported to also bind and inhibit human IL-27.

InVivoMAb anti-mouse IL-27 p28 Specifications

Isotype

Mouse IgG2a, κ

Recommended Isotype Control(s)InVivoMAb mouse IgG2a isotype control, unknown specificity(BE0085)
Recommended InVivoPure Dilution BufferInVivoPure pH 7.0 Dilution Buffer(IP0070)
Immunogen

Mouse IL-27

Reported Applications
  • in vivo IL-27 p28 neutralization
  • in vitro IL-27 p28 neutralization
  • Flow cytometry
Formulation
  • PBS, pH 7.0
  • Contains no stabilizers or preservatives
Endotoxin
  • <2EU/mg (<0.002EU/μg)
  • Determined by LAL gel clotting assay
Purity
  • >95%
  • Determined by SDS-PAGE
Sterility

0.2 μM filtered

Production

Purified from tissue culture supernatant in an animal free facility

Purification

Protein A

Molecular Weight

150 kDa

RRID

AB_2819053

Storage

The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.

品牌介绍
Bio X Cell采用最先进的发酵技术;包括搅拌罐发酵罐和波包系统;我们的生产能力从5升到500升不等。Bio X Cell提供从现有杂交瘤细胞系产生的抗体的生产和纯化服务。这些杂交瘤通常在客户的实验室中开发或在公共领域可用。该服务包括在细胞培养物中发酵杂交瘤,通过离心收获细胞培养上清液以及通过30 kDa超滤浓缩。通过蛋白A或G亲和色谱进行纯化。将纯化的抗体透析到PBS中并过滤除菌。我们所有定制产品的内毒素水平<2EU / mg。我们还提供冻结细胞系,现场细胞系存储和MAP测试的额外费用。