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BioXcell/InVivoMab anti-mouse IL-3/REGULAR: 50MG/BE0282-R050mg
About InVivoMab anti-mouse IL-3
The MP2-8F8 monoclonal antibody reacts with mouse IL-3, a pleiotropic cytokine produced primarily by activated T cells but also by activated mast cells, keratinocytes and neurons/astrocytes. IL-3 is highly species-specific, mature human and mouse IL-3 share only 29% sequence identity and human IL-3 does not show activity on mouse cells. IL-3 can stimulate the proliferation and differentiation of megakaryocytes, neutrophils, and macrophages from bone marrow cultures. Additionally, IL-3 also affects the functional activity of mature mast cells, basophils, eosinophils and macrophages. The MP2-8F8 antibody has been reported to neutralize the bioactivity of natural or recombinant IL-3 as well as stimulate basophil proliferation when administered as a complex with IL-3.
InVivoMab anti-mouse IL-3 Specifications
| Isotype | Rat IgG1 |
| Recommended Isotype Control(s) | InVivoMAb rat IgG1 isotype control, anti-horseradish peroxidase(BE0088) |
| Recommended InVivoPure Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer(IP0070) |
| Immunogen | COS-expressed, recombinant mouse IL-3 |
| Reported Applications |
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| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2 μM filtered |
| Production | Purified from tissue culture supernatant in an animal free facility |
| Purification | Protein G |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
| RRID | AB_2687805 |
| Molecular Weight | 150 kDa |
